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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Trends Endocrinol Metab. 2022 Nov 23;34(1):21–33. doi: 10.1016/j.tem.2022.11.001

Table 2.

Copper therapeutics

Compound Potential therapeutic application Chemical structure Refs
Copper ionophores
Elesclomol Menkes disease, Mitochondrial disorders, Cancer graphic file with name nihms-1852816-t0001.jpg [80, 86]
CuATSM ALS, Parkinson’s disease, Cancer graphic file with name nihms-1852816-t0002.jpg [87, 88, 99]
CuGTSM Alzheimer’s disease, Cancer graphic file with name nihms-1852816-t0003.jpg [89, 99]
Disulfiram Cancer, Alcohol abuse drug graphic file with name nihms-1852816-t0004.jpg [79]
Copper chelators
D-penicillamine Wilson disease graphic file with name nihms-1852816-t0005.jpg [90, 92]
Trientine Wilson disease graphic file with name nihms-1852816-t0006.jpg [90, 92]
Tetrathiomolybdate Wilson disease graphic file with name nihms-1852816-t0007.jpg [90, 92, 93]