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. 2022 Dec 22;5:1402. doi: 10.1038/s42003-022-04349-x

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Proteins identified in the surface and in total minus surface fractions were compared by fold change and t-test statistical analysis. a The bar plot represents the ratio of the 25 most enriched proteins in surface and in total minus surface fractions. b The volcano plot represents fold changes and P-value for proteins identified at least in two samples. c Abundance in normalized peptide spectrum matches (nPSMs) of known sEV markers in the surface fraction of SF-sEVs.