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. 2022 Dec 9;10:1053217. doi: 10.3389/fbioe.2022.1053217

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Copyright © 2022 Lu, Lu, Liu, Li, Fang, Chen and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Native EVs are derived from different sources for wound healing. (A) Application of native EVs to inhibit inflammation, such as promoting macrophage polarization toward M2, increasing the expression of anti-inflammatory cytokines, and decreasing the expression of proinflammatory cytokines. (B) Functions of native EVs to promote cell proliferation and migration. (C) Effects of native EVs to enhance angiogenesis and up-regulate the expression of growth factors. (D) Using native EVs to regulate remodeling by promoting collagen synthesis, re-epithelization, and scarless wound healing.