FIGURE 4.

Differential swim intensity-dependent interactions between vestibular sensory signals and locomotor ECs. (A) Schematic depicting the gating of vestibulo-ocular signaling during intense swimming in older larvae or in rapidly-swimming young larvae, leading to ocular motor performance remaining coordinated with tail undulations exclusively through an ascending drive from spinal ECs; during less intense or slow swimming (B), ocular motor performance results from an additive relationship between the predictive ECs and horizontal semicircular canal signals, with the latter now contributing significantly to compensatory eye motion; the two processing configurations gradually change their respective dominance depending on swimming strength and frequency (bottom schematic). Abd, abducens motoneurons; CPG, central pattern generator; VOR, vestibulo-ocular reflex; VS, vestibulo-spinal pathway.