Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 22;12:22154. doi: 10.1038/s41598-022-26391-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The STK4 gene expression pattern, obtained at the Broad Institute portal. (A) STK4 mRNA expression in various tumor cell lines, according to RNAseq.; (B) STK4 mRNA expression according to microarray studies; (C) the STK4 gene copy number ratio, calculated based on mRNA expression in normal tissue and cancer cell lines (16). Note that the highly expressed STK4 in Burkitt lymphoma has only 2 copies (20 × 2 = 2), while in solid tumors there is a gain in copy number values (up to 3 copies in EC cell lines: 20.75 × 2 = 3.3); (D) methylation of the STK4 promoter, obtained by reduced representation bisulfite sequencing (RRBS). The STK4 promoter methylation is quite high in EC, prostate cancer, and breast cancer cell lines, i.e., in hormone-driven cancers of the human reproductive system. RMA robust multichip averaging, relative units of the signal intensity (see detailed description at https://portals.broadinstitute.org/ccle). AML acute myeloid leukemia, T-cell ALL acute T-cell lymphocytic leukemia, NSC lung non-small cell lung tumor.