Table 2.

Echocardiographic data for wild-type (WT) mice transduced or not with AAV expressing HDAC6 (AAV-HDAC6) at 2, 3, 4 and 5 months of age

	WT	AAV-HDAC6	WT	AAV-HDAC6	WT	AAV-HDAC6	WT	AAV-HDAC6
Age	2 months	2 months	3 months	3 months	4 months	4 months	5 months	5 months
n	3	3	3	3	3	3	3	3
Time (ms)	89.3 ± 0.68	93.4 ± 2.3	93.4 ± 2.1	92.9 ± 1.2	92.5 ± 0.4	91.9 ± 0.9	94.4 ± 0.6	93.5 ± 5.6
Heart rate (bpm)	671.7 ± 5.2	643.3 ± 15.79	642.8 ± 14.61	645.6 ± 9.03	643.9 ± 4.65	653.3 ± 7.04	635.95 ± 4.16	646.3 ± 37.64
Cardiac output (l/min)	0.066 ± 0.003	0.083 ± 0.008	0.08 ± 0.005	0.083 ± 0.008	0.073 ± 0.008	0.076 ± 0.008	0.070 ± 0.005	0.070 ± 0.000
IVSd (cm)	0.063 ± 0.003	0.066 ± 0.003	0.070 ± 0.000	0.066 ± 0.003	0.070 ± 0.005	0.066 ± 0.003	0.073 ± 0.003	0.063 ± 0.003
LVDd (cm)	0.37 ± 0.008	0.39 ± 0.01	0.39 ± 0.01	0.40 ± 0.01	0.39 ± 0.02	0.041 ± 0.011	0.38 ± 0.01	0.42 ± 0.008
LVPWd (cm)	0.06 ± 0.000	0.063 ± 0.003	0.06 ± 0.005	0.063 ± 0.003	0.056 ± 0.008	0.068 ± 0.005	0.070 ± 0.0046	0.07 ± 0.005
IVSs (cm)	0.11 ± 0.005	0.11 ± 0.003	0.11 ± 0,003	0.12 ± 0.003	0.10 ± 0.003	0.10 ± 0.004	0.12 ± 0.005	0.09 ± 0.003**
LVDs (cm)	0.23 ± 0.010	0.22 ± 0.013	0.21 ± 0.006	0.22 ± 0.012	0.24 ± 0.025	0.27 ± 0.013	0.21 ± 0.006	0.31 ± 0.008**
LVPWs (cm)	0.11 ± 0.003	0.11 ± 0.011	0.12 ± 0.003	0.11 ± 0.003	0.11 ± 0.003	0.11 ± 0.008	0.12 ± 0.005	0.08 ± 0..003*
LVED vol (ml)	0.13 ± 0.008	0.16 ± 0.016	0.14 ± 0.012	0.15 ± 0.017	0.15 ± 0.024	0.17 ± 0.014	0.14 ± 0.011	0.19 ± 0.008
LVES vol (ml)	0.033 ± 0.003	0.033 ± 0.003	0.026 ± 0.003	0.026 ± 0.006	0.036 ± 0.012	0.05 ± 0.005	0.026 ± 0.003	0.08 ± 0.005***
EF (%)	75.59 ± 2.25	80.80 ± 1.24	82.51 ± 0.68	81.52 ± 1.129	76.02 ± 3.425	70.51 ± 4.172	81.29 ± 0.101	57.69 ± 0.92****
FS (%)	38.74 ± 1.948	43.58 ± 1.214	45.29 ± 0.74	44.31 ± 1.16	39.28 ± 2.83	34.85 ± 3.18	43.98 ± 0.10	25.92 ± 0.54****
LV eject vol (ml)	0.10 ± 0.011	0.12 ± 0.021	0.12 ± 0.015	0.13 ± 0.026	0.11 ± 0.021	0.12 ± 0.026	0.11 ± 0.015	0.11 ± 0.010
h/r	0.33 ± 0.008	0.32 ± 0.022	0.33 ± 0.021	0.33 ± 0.032	0.31 ± 0.023	0.31 ± 0.019	0.37 ± 0.02	0.31 ± 0.001*

Values are means ± SEM. Statistics: one-way ANOVA followed by Tukey’s multiple comparison test.

IVS inter ventricular septum, LVD left ventricular diameter, LVPW left ventricular posterior wall; LVED left ventricular end diastolic, LVES left ventricular end systolic, EF ejection fraction, FS fractional shortening, s systole, d diastole.

*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001 between WT mice and WT mice transduced with AAV-HDAC6.