Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 22;12:22152. doi: 10.1038/s41598-022-26504-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Ca_V1.2 cKO mice display slower gait but no deficit in cerebellar-dependent associative motor learning on the Erasmus Ladder task. (a) Neuronal Ca_V1.2 cKO mice had fewer missteps than CTRL littermates on day 1 which resolved on days 2–4. (b) We observed a main effect of day in the use of long steps, with no sex or genotype-dependent effects. Therefore, on average all groups use more long steps over the course of training, representing normal gait adaptation. (c) Neuronal Ca_V1.2 cKO mice had a longer average step time compared to CTRL littermates. Males also had a longer average step time compared to females. (d) All groups learn to jump over a displaced peg in response to a tone cue, shown as a decrease in step time between days 5 and days 6–8. Post hoc testing revealed that CTRL mice had longer post-perturbation step times on day 5 compared to cKO mice, but this was not observed on days 6–8, suggesting that all groups successfully learn to associate the tone with the displaced peg, representative of cerebellum-dependent associative learning. No sex-dependent effects were detected. Data are expressed as mean ± s.e.m, using ErasmusLadder 2.0.214, www.noldus.com/erasmusladder.