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. 2022 Dec 9;13:1079566. doi: 10.3389/fphar.2022.1079566

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Copyright © 2022 Huang, Zhao, Zhang, Zhao, Zhang, Chen and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-enrichment and diagnostic values of CLST, NKT, MDSC, and aCD4 in CHB and HBV-LF. (A) Boxplot comparing immune signals between patients with chronic HBV infection and normal tissues from patients without HBV infection. (B) Boxplot comparing immune signals between patients with inflammation (G ≥ 1) and those without inflammation (G = 0). (C) Boxplot comparing immune signals between patients with liver fibrosis (S ≥ 1) and those without liver fibrosis (S = 0). (D) Venn diagram of upregulated LILs. (E,F) Correlation heatmap showing the co-enrichment pattern of CLST and LILs in CHB and HBV-LF. (G–I) ROC curves of CLST and LILs for predicting liver injury and LF.