FIGURE 5.

The prognostic value of nutritional utilization of the amino acid-associated gene signature in HBV-HCC (A) Lysosomal nutrient generation and nutritional utilization of amino acids for tumor cell growth. LYSET (TEME251), ATF4, VPS18, RAB7A, SLC7A5, TGFBRAP1, and GNPTAB were involved in this process. (B–H) Plots depict the KM survival curves for each nutritional utilization of amino acid-associated genes in HBV-HCC patients from the CHCC cohort divided into low and high expression groups according to the gene expression value. (I) KM survival curves for OS in tumor tissues of HBV-HCC patients from CHCC cohort with a high ES of the “nutritional utilization of amino acid-associated gene” signature and a low ES of the “nutritional utilization of amino acid-associated gene” signature. (J) Differences in the enrichment levels of the “nutritional utilization of amino acid-associated gene” signature between HBV-HCC patients from the CHCC cohort in the CLST^highaCD4^high subgroup and those in the CLST^lowaCD4^low subgroup.