FIG. 5.

Effect of TNF-α on survival of mice infected with recombinant BCG. TNF-KO mice (solid symbols) or wild-type mice (open symbols) were infected with BCG-vector (squares) or BCG-TNF (circles). Results expressed as percent survival represent the means of two independent experiments for each dose with 12 mice per group. A significant (P < 0.001) difference in survival of TNF-KO mice infected with low doses of BCG-vector versus those infected with BCG-TNF was noted. (For P values for the high doses of infection, see text.)