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. 2022 Dec 9;13:1046130. doi: 10.3389/fendo.2022.1046130

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Copyright © 2022 Niu, Chen, Chen, Ren, Yue, Pan, Zhao, Li and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of semaglutide on liver metabolomics in HFD-induced NAFLD model. (A) PCA was utilized to analyze the metabolites from NFD and HFD-fed rats with and without semaglutide treatment for 24 weeks; (B, C) OPLS-DA was utilized to analyze the metabolites between NCD and HFD group or HFD and HFD+sema group; PLS-DA, partial least squares discriminant analysis; OPLS-DA, orthogonal partial least squares discriminant analysis; NAFLD, non-alcoholic fatty liver disease.