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. 2022 Dec 9;13:1046130. doi: 10.3389/fendo.2022.1046130

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Copyright © 2022 Niu, Chen, Chen, Ren, Yue, Pan, Zhao, Li and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Heatmap analysis of differential metabolites with VIP of OPLS-DA greater than 1, and P-value of Student’s test less than 0.05; VIP, variable important in projection; OPLS-DA, orthogonal partial least squares discriminant analysis. (B) Heatmap Pearson’s correlation analysis was conducted to evaluate the correlation of differential metabolites. Some metabolites were negatively related (blue), and some were positively related (red).