Table 2.
The DEPs between HFD/Semaglutide(FC value>1, upregulated proteins, FC value<1, downregulated proteins).
| KEGG | Metabolites | Annotation | FC value | P value |
|---|---|---|---|---|
| C00422 | TG(16:0/18:1(9Z)/18:2(9Z,12Z) | Regulation of lipolysis in adipocytes | 1.40119 | 0.02682 |
| C00696 | Prostaglandin D2 | Neuroactive ligand-receptor interaction | 3.9372 | 0.04731 |
| C00245 | Taurine | Neuroactive ligand-receptor interaction | 2.253 | 0.00295 |
| C00079 | L-Phenylalanine | Aminoacyl-tRNA biosynthesis | 0.532 | 0.00072 |
| C00082 | L-Tyrosine | Aminoacyl-tRNA biosynthesis | 0.52658 | 0.00017 |
| C00148 | L-Proline | Aminoacyl-tRNA biosynthesis | 0.74646 | 0.0108 |
| C00183 | L-Valine | Aminoacyl-tRNA biosynthesis | 0.45524 | 0.00679 |
| C00407 | L-Isoleucine | Aminoacyl-tRNA biosynthesis | 0.70402 | 0.00783 |
| C00020 | Adenosine monophosphate | Regulation of lipolysis in adipocytes | 0.55494 | 0.00972 |
| C01772 | 2-Hydroxycinnamic acid | Phenylalanine metabolism | 0.62917 | 0.00091 |
| C00077 | L-Ornithine | Arginine biosynthesis | 0.73271 | 0.0135 |
| C00624 | N-Acetyl-L-glutamic acid | Arginine biosynthesis | 0.58908 | 0.00803 |
| C07471 | Methacholine | 0.3277 | 0.00881 |