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Inhibition of GPX4 induced ferroptosis. Cystine is transported into cells by System xc—and transformed into cysteine by TXNRD1, which further synthesizes GSH. GPX4 uses GSH to remove the phospholipid peroxide (PLOOH). The decrease of GSH leads to the weakening of GPX4’s scavenging effect on lipid peroxides, thus inducing ferroptosis.
