Table 5.
Adverse events.
| Adverse Events | Overall | ICI+Lenva | ICI+Others | |||
|---|---|---|---|---|---|---|
| Any grade | Grade 3-4 | Any grade | Grade 3-4 | Any grade | Grade 3-4 | |
| Summary | 85 (100) | 46 (54.12) | 58 (100) | 27 (46.55) | 27 (100) | 19 (70.37) |
| Fatigue | 39 (45.88) | 5 (5.88) | 24 (41.38) | 1 (1.72) | 15 (55.56) | 4 (14.81) |
| Hyperbilirubinemia | 33 (38.82) | 4 (4.71) | 23 (39.66) | 2 (3.45) | 10 (37.04) | 2 (7.41) |
| Hypoalbuminemia | 32 (37.65) | 1 (1.18) | 24 (41.38) | 1 (1.72) | 8 (29.63) | 0 (0) |
| Aspartate aminotransferase increased | 31 (36.47) | 6 (7.06) | 20 (34.48) | 5 (8.62) | 11 (40.74) | 1 (3.7) |
| Hypertension | 30 (35.29) | 10 (11.76) | 23 (39.66) | 5 (8.62) | 7 (25.93) | 5 (18.52) |
| Decreased appetite | 29 (34.12) | 1 (1.18) | 22 (37.93) | 0 (0) | 7 (25.93) | 1 (3.7) |
| Hypothyroidism | 21 (24.71) | 0 (0) | 16 (27.59) | 0 (0) | 5 (18.52) | 0 (0) |
| Alanine aminotransferase increased | 19 (22.35) | 4 (4.71) | 14 (24.14) | 3 (5.17) | 5 (18.52) | 1 (3.7) |
| Diarrhea | 18 (21.18) | 7 (8.24) | 15 (25.86) | 6 (10.34) | 3 (11.11) | 1 (3.7) |
| Decreased platelet count | 18 (21.18) | 3 (3.53) | 11 (18.97) | 3 (5.17) | 7 (25.93) | 0 (0) |
| Abdominal pain | 17 (20) | 5 (5.88) | 12 (20.69) | 4 (6.9) | 5 (18.52) | 1 (3.7) |
| Rash | 16 (18.82) | 5 (5.88) | 12 (20.69) | 3 (5.17) | 4 (14.81) | 2 (7.41) |
| Anemia | 15 (17.65) | 5 (5.88) | 10 (17.24) | 2 (3.45) | 5 (18.52) | 3 (11.11) |
| Electrolyte disturbance | 15 (17.65) | 2 (2.35) | 10 (17.24) | 2 (3.45) | 5 (18.52) | 0 (0) |
| Gastrointestinal bleeding | 14 (16.47) | 5 (5.88) | 8 (13.79) | 3 (5.17) | 6 (22.22) | 2 (7.41) |
| Proteinuria | 14 (16.47) | 3 (3.53) | 12 (20.69) | 3 (5.17) | 2 (7.41) | 0 (0) |
| Ascites | 13 (15.29) | 1 (1.18) | 11 (18.97) | 1 (1.72) | 2 (7.41) | 0 (0) |
| Decreased white blood cell count | 13 (15.29) | 1 (1.18) | 10 (17.24) | 1 (1.72) | 3 (11.11) | 0 (0) |
| Fever | 10 (11.76) | 2 (2.35) | 5 (8.62) | 1 (1.72) | 5 (18.52) | 1 (3.7) |
| Nausea | 8 (9.41) | 1 (1.18) | 5 (8.62) | 1 (1.72) | 3 (11.11) | 0 (0) |
| Abdominal distension | 7 (8.24) | 0 (0) | 5 (8.62) | 0 (0) | 2 (7.41) | 0 (0) |
| Edema | 7 (8.24) | 0 (0) | 6 (10.34) | 0 (0) | 1 (3.7) | 0 (0) |
| Gingival bleeding | 7 (8.24) | 0 (0) | 4 (6.9) | 0 (0) | 3 (11.11) | 0 (0) |
| Vomiting | 7 (8.24) | 2 (2.35) | 6 (10.34) | 2 (3.45) | 1 (3.7) | 0 (0) |
| Decreased weight | 7 (8.24) | 0 (0) | 6 (10.34) | 0 (0) | 1 (3.7) | 0 (0) |
| Hand-foot syndrome | 6 (7.06) | 2 (2.35) | 6 (10.34) | 2 (3.45) | 5 (18.5) | 2 (7.41) |
| Pneumonia | 3 (3.53) | 3 (3.53) | 1 (1.72) | 1 (1.72) | 2 (7.41) | 2 (7.41) |
| Peptic ulcer | 1 (1.18) | 0 (0) | 1 (1.72) | 0 (0) | 0 (0) | 0 (0) |