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. 2022 Dec 9;13:974468. doi: 10.3389/fphar.2022.974468

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Copyright © 2022 Ko, Jee, Lee, Jang and Jung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combination effect of OP-D and 5-FU or doxorubicin in HCT116^p53+/+ cells. (A) HCT116^p53+/+ cells were treated with or without OP-D (20 or 40 μM) and 5-FU (10 μM) for 24 h. (B) HCT116^p53+/+ cells were treated with or without OP-D (20 or 40 μM) and doxorubicin (0.3 μM) for 24 h. (C) Then, cells were collected and performed by Western blotting with various antibodies. (D) Then, cells were collected and performed by Western blotting with various antibodies. Data represent means ± SD. **p < 0.01, ***p < 0.005, ****p < 0.001, ##p < 0.01, ###p < 0.005, ####p < 0.001.