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OP-D inhibits c-Myc via CNOT2 in HCT116p53+/+ cells. HCT116p53+/+ cells were transfected with CNOT2 siRNA or control siRNA (80 nM) for 50 h. And then, cells were treated with OP-D (0 or 40 μM) for 24 h. Cell lysates were performed for Pro-PARP, c-Myc, CNOT2, and β-actin by Western blotting. Data represent means ± SD. *p < 0.05, **p < 0.01, ***p < 0.005, *****pp < 0.001 versus untreated control.
