TABLE 3.
Total, indirect, and direct effects in terms of mean differences with 95% percentile bootstrap confidence intervals for mediation by transportation, sports, hobbies, and work in the association between AD stages and life satisfaction
| Comparison | Effect of stage on life satisfaction ‡ (Total effect) | Mediator(s) | Effect explained by mediator (Indirect effect ‡ ) | Effect not explained by mediator (Direct effect ‡ ) |
|---|---|---|---|---|
| Dementia vs. SCD | −3.24*, † (−5.53; −0.96) | Transportation | −1.81 (−3.22; −0.49)*, † | −1.44 (−4.09; 1.04) |
| Transportation and sports | −1.97 (−3.43; −0.64)*, † | −1.27 (−3.78; 1.16) | ||
| Transportation and hobbies | −1.78 (−3.23; −0.48)*, † | −1.46 (−3.93; 1.14) | ||
| Transportation and (voluntary) work | −2.52 (−4.20; −1.06)*, † | −0.72 (−3.46; 1.76) | ||
| Dementia vs. MCI | −3.42*, † (−5.67; −1.17) | Transportation | −1.09 (−2.00; −0.29)*, † | −2.33 (−4.49; −0.13)* |
| Transportation and sports | −1.02 (−2.03; −0.14)*, † | −2.39 (−4.56; −0.13)* | ||
| Transportation and hobbies | −1.36 (−2.32; −0.41)*, † | −2.06 (−4.02; 0.05) | ||
| Transportation and (voluntary) work | −1.29 (−2.30; −0.32)*, † | −2.13 (−4.34; 0.15) | ||
| MCI vs. SCD | 0.17 (−2.42; 2.78) | Transportation | −0.72 (−1.63; −0.13)*, † | 0.89 (−0.60; 3.22) |
| Transportation and sports | −0.95 (−1.94; −0.18)*, † | 1.12 (−1.38; 3.48) | ||
| Transportation and hobbies | −0.42 (−1.41; 0.39) | 0.59 (−1.91; 2.94) | ||
| Transportation and (voluntary) work | −1.23 (−2.38; −0.45)*, † | 1.41 (−1.25; 3.87) |
Abbreviations: MCI, mild cognitive impairment; SCD, subjective cognitive decline.
*
Significant based on p < 0.05.
†
Significant based on Bonferroni‐corrected p‐value of <0.017 (98.3% percentile bootstrap confidence intervals not shown).
‡
All effect estimates are adjusted for age, sex, education and comorbidities.
An indirect effect is the part of the total effect of AD stage on life satisfaction that is explained by the mediator.