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Population parameter estimates from the final two-compartment PK model
| Parameter | Mean | Median | SD | Shrinkage (%) |
|---|---|---|---|---|
| Clearance (L/h) | 0.416 | 0.345 | 0.363 | 9.539 |
| Volume (L) | 4.566 | 3.698 | 4.518 | 5.930 |
| KCP (h−1) | 2.222 | 0.218 | 3.351 | 10.769 |
| KPC (h−1) | 2.951 | 0.484 | 4.070 | 17.928 |
KCP, first-order rate constant for the AmBisome distribution from the central to the peripheral compartment; KPC, first-order rate constant for the AmBisome distribution from the peripheral to the central compartment.
