Table 3.

ORs of developing grade 3 or 4 laboratory-defined adverse events during AmBisome-containing induction therapy

Event	OR of event occurring with a unit increase in AUC0–24, estimate (P value for estimate)	OR of event occurring with a unit increase in AUC0–168
Anaemia	1.0 (0.47)	1.0 (0.29)
Creatinine increase	1.0 (0.43)	1.0 (0.51)
Hypokalaemia	1.0 (0.89)	1.0 (0.70)
Elevated ALT	1.0 (0.82)	1.0 (0.85)

Anaemia was defined as haemoglobin ≤9.0 g/dL in males or ≤8.5 g/dL in females; creatinine increase was defined as ≥207 μmol/L; hypokalaemia was defined as potassium decrease to <2.5 mmol/L; elevated ALT was defined as an increase to ≥ 180 IU/L.