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. 2022 Dec 23;13:7907. doi: 10.1038/s41467-022-35590-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b Expression levels of soluble ACE2 and MT1-MMP in the plasma of young human subjects and aged human subjects were measured by ELISA (n = 21 young people & 23 old people) (unpaired two-tailed t-test). The data are shown as the means ± SEM. c Comparison of MMP14 expression levels in young human subjects and elderly human subjects by analysis of single-cell transcriptome obtained from human lung and airway cells (unpaired two-tailed t-test). Boxplots show the median (central line), the 25–75% interquartile range (IQR) (box limits), the ±1.5 × IQR (whiskers). (n = 25 for young subjects; n = 11 for old subjects) d The positive correlation between plasma MT1-MMP and soluble ACE2 in human plasma (p = 000008, two-tailed; R = 0.4646, n = 43; Spearman’s correlation) Dashed lines represent the 95% confidence interval for the lines of regression presented in the figure. Source data are provided as a Source Data file.