TABLE 3.

Gene ontology (GO) clustering and enrichment analyses of candidate genes identified by genome-wide iHS and XP-CLR scans in the high-altitude cattle populations.

GO term	Count	p value	Fold change	Gene
GO: 0005216∼ion channel activity	15	4.8E-06	4.5	ITPR2, KCNJ8, GPR89A, TRPM3, CLCA1, NOX5, GRIK3, CACNG2, SLC26A, CLCA4, GABRB2, ABCC9, KCNQ3, CLCA2, TPC3
GO: 0001666∼response to hypoxia	7	9.3E-04	6.1	ITPR2, MB, CBFA2T3, SRF, VEGFC, HMOX1, ARNT
GO: 0034101∼erythrocyte homeostasis	6	1.0E-03	7.7	MAFB, MB, FOXO3, SRF, HMOX1, ARID4A
bta04924: Renin secretion	6	2.9E-04	9.9	ITPR2, CLCA1, PRKACB, CLCA4, CLCA2, GUCY1A2
GO: 1901700∼response to oxygen-containing compound	19	1.0E-04	2.8	DUSP10, ITPR2, KCNJ8, IMPACT, NDUFS4, SESN3, AVPR1A, STAT1, PDX1, PTK7, SLC11A1, ADH5, EFNA5, SSTR2, NOX4, HRH4, CRY2, ENPP1, MZB1
GO: 0008217∼regulation of blood pressure	6	2.1E-03	6.6	AVPR1A, POMC, GRIP2, ERAP1, ADH5, MYH6
GO: 0020037∼heme binding	5	2.1E-02	4.7	MB, HMOX1, CYP4F2, GUCY1A2, ENSBTAG00000048257
GO: 0016887∼ATPase activity	8	1.3E-02	3.1	ABCB10, ATP6V0A1, YTHDC2, MYO10, ABCC9, ATP6V1G1, MYH7, MYH6
GO: 0042593∼glucose homeostasis	6	5.1E-03	5.3	SESN3, POMC, PDX1, FOXO3, CRY2, NOX4