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. 2022 Dec 1;11(12):1455. doi: 10.3390/pathogens11121455

Table 2.

The interpretive criteria and terms used for the evaluation of AST data and the proposed interpretive criteria and terms for biocide susceptibility testing of planktonic cells.

Antimicrobial Susceptibility Testing Biocide Susceptibility Testing
Definitions Interpretive
Criteria
Proposed Definitions Interpretive
Criteria
Clinical resistance
Isolates are not inhibited by the concentrations of the agent usually achievable with normal dosage schedules at the site of infection and/or test results fall into the range in which specific microbial resistance mechanisms are likely, and clinical efficacy of the agent has not been reliably shown.
Clinical
breakpoints
Resistance (application-related)
Isolates are neither killed nor inhibited by a biocide concentration attained in practice.
In-use
concentrations
Wildtype/Non-wildtype
Bacterial populations are separated into those without and with acquired resistance mechanisms based on their phenotypes.
Epidemiological cutoff values Wildtype/Non-wildtype
A non-wildtype isolate is neither killed nor inhibited by a biocide concentration at which the majority of isolates of the same species are killed or inhibited.
Epidemiological cutoff values