Table 2.
Antimicrobial Susceptibility Testing | Biocide Susceptibility Testing | ||
---|---|---|---|
Definitions | Interpretive Criteria |
Proposed Definitions | Interpretive Criteria |
Clinical resistance Isolates are not inhibited by the concentrations of the agent usually achievable with normal dosage schedules at the site of infection and/or test results fall into the range in which specific microbial resistance mechanisms are likely, and clinical efficacy of the agent has not been reliably shown. |
Clinical breakpoints |
Resistance (application-related) Isolates are neither killed nor inhibited by a biocide concentration attained in practice. |
In-use concentrations |
Wildtype/Non-wildtype Bacterial populations are separated into those without and with acquired resistance mechanisms based on their phenotypes. |
Epidemiological cutoff values |
Wildtype/Non-wildtype A non-wildtype isolate is neither killed nor inhibited by a biocide concentration at which the majority of isolates of the same species are killed or inhibited. |
Epidemiological cutoff values |