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Concentration-dependent inhibitory effects of decynium22 on (A) hOCT2-, (B) mOct2-mediated 14C-metformin transport and (C) hOCT2-, (D) mOct2-mediated 3H-MPP transport in transfected HEK293 cells. Each data point represents the mean inhibitory effect (%) calculated from net-uptake of two independent experiments carried out in triplicate ± average deviation. IC50 values were calculated by sigmoidal 4Hill equation using Sigma Plot version 13.0 software.
