ABCB1 |
ABC transporters multidrug resistance 1 |
ABCG2 |
ABC transporters |
ADMET |
Chemical absorption, distribution, metabolism, excretion, and toxicity |
ADT |
Androgen deprivation therapy |
Ag |
Agonist |
Akt |
Serine/threonine kinase |
ALK |
Anaplastic lymphoma kinase |
AMPK/mTOR |
AMP-activated protein kinase/mechanistic target of rapamycin kinase |
APC |
Adenomatous polyposis coli gen |
AR |
Androgen receptor |
AZA |
Acetazolamide |
BAX |
BCL2 associated X protein |
BBB |
Blood–brain barrier |
Bcl-XL |
B-cell lymphoma-extra large |
BTB |
Blood–tumor barrier |
BCL-2 |
B-cell lymphoma 2 |
BTCP |
2-bicyclo[2.2.1]hept-5-enyl-1H-1,3,7,8-tetraazacyclopenta[l]phenanthrene |
CA |
Carbonic anhydrase |
cAMP |
Cyclic adenosine monophosphate |
CDK2 |
Cyclin dependent kinase 2 |
c-Met |
Mesenchymal epithelial transition factor |
DA |
Diels–Alder |
DDS |
Drug delivery systems |
DNA |
Deoxyribonucleic acid |
EC50
|
Half maximal effective concentration |
EGFR |
Epidermal growth factor receptor |
EMT |
Epithelial mesenchymal transmission |
ER |
Estrogen receptors |
ERK |
Estrogen receptor kinase |
FAM46C |
Non-canonical poly(A) polymerase protein |
FDA |
Food drug administration |
HDAC |
Histone deacetylase |
HUVEC |
Human Umbilical Vein Endothelial Cell |
IARC |
International Agency for Research on Cancer |
IC50
|
Half maximal inhibitory concentration |
InR |
Insulin receptor |
JNK |
c-Jun N-terminal kinase |
Ki |
Inhibitory constant |
LC3-IIB |
Microtubule-associated protein 1A/1B-light chain 3-phosphatidylethanolamine conjugate B |
MALT1 |
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
MAP |
Mitogen-activated protein |
MCL-1 |
Myeloid cell leukemia-1 |
MEK1/2 |
Mitogen-activated protein kinase kinases 1/2 |
MOF |
Metal–organic framework |
MT |
Mutant type |
PDAC |
Pancreatic ductal adenocarcinoma |
P-gp |
MDR1/P-glycoprotein |
Ras |
Rat sarcoma virus |
RNS |
Reactive nitrogen species |
ROS |
Reactive oxygen species |
SAR |
Structure–activity relationship |
SDHB |
Succinate dehydrogenase complex subunit b |
SI |
Selectivity Index |
SIRT7 |
Sirtuin protein 7 |
SQSTM1/p62 |
Sequestosome 1 |
TGI |
Total growth inhibition |
TNF |
Tumor necrosis factor |
TRPM8 |
Transient receptor potential cation channel subfamily M member 8 |
VEGFR-2 |
Vascular endothelial growth factor receptor 2 |
WT |
Wild type |