Figure 3.
Guanosine prevents Aβ1–42-induced ROS production in mice hippocampal slices. Mice subjected to i.c.v. Aβ1–42 infusion (400 pmol/site) received guanosine (GUO, 8 mg/kg, i.p.) for seven days. On the eighth day, animals were euthanized, and hippocampal slices were analysed for ROS production (A), cellular viability through MTT assay (B), and cellular membrane damage through Propidium iodide (PI) incorporation (C). Values expressed as mean + S.E.M (n = 6–9) * p ≤ 0.05 compared with vehicle-treated group. # p ˂ 0.05 compared with Aβ1–42 group. (Two-way ANOVA followed by Tukey’s test).