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Evaluation of anhedonic-like behaviour in mice following guanosine treatment and Aβ1–42 i.c.v. infusion. Mice subjected to Aβ1–42 infusion (400 pmol/site) received guanosine (GUO, 8 mg/kg, i.p.) for nine days. On the tenth day, mice were subjected to the sucrose splash test and the latency to initiating grooming (A) and the total time spent in grooming activity (B) were measured. Values expressed as mean + S.E.M (n = 7–8). (Two-way ANOVA followed by Tukey’s test).
