Table 1.

Typical examples of MOF–based nanocarriers for cancer therapy.

MOFs	Metal Ions/Clusters	Organic Linkers	Loaded Agents	Therapeutic Modalities	Refs
Fe–MIL–100	Fe	1,3,5–benzene tricarboxylic acid	DOX	Drug release in vitro	[5]
Fe–MIL–100	Fe	1,3,5–benzene tricarboxylic acid	Paclitaxel and gemcitabine	Chemotherapy	[86]
Fe–NDC	Fe	2,6–naphthalenedicarboxylic acid	Calcein	Chemotherapy	[87]
PCN–224	Zr	H2TCPP	N.A.	Photodynamic therapy	[88]
Fe–cit MOF	Fe	Citric acid	N.A.	Cancer therapy	[89]
ZIF–90	Zn	Imidazole–2–carboxaldehyde	Ce6	Cancer therapy	[90]
Cr–MIL–100	Cr	1,3,5–benzene tricarboxylic acid	Ibuprofen	Drug release in vitro	[91]
Cr–MIL–101	Cr	1,4–benzenedicarboxylic acid	Ibuprofen	Drug release in vitro	[91]
ZIF–8	Zn	2–methylimidazole	5–Fu	Drug release in vitro	[92]
ZIF–8	Zn	2–methylimidazole	DOX	Chemotherapy	[93]
Cu–doped ZIF–8	Zn, Cu	2–methylimidazole	O2	PDT and CDT	[94]
PCN–224	Zr	H2TCPP	N.A.	Photodynamic therapy	[95]
ZIF–8	Zn	2–methylimidazole	PolyIC	Immunotherapy	[96]
ZIF–90	Zn	Imidazole–2–carboxaldehyde	Protein	Gene therapy	[97]
ZIF–82	Zn	2–nitroimidazole and 1H– imidazole–4–nitrile	Catalase DNAzymes	CDT	[98]
Fe–MIL–100	Fe	1,3,5–benzene tricarboxylic acid	Plasma amine oxidase	CDT	[99]
Fe–MIL–88B	Fe	1,4–benzenedicarboxylic acid	Photoacid molecules	Anti–metastasis and CDT	[100]