TLR4 expression is minimal in the IECs of healthy controls but significantly increased in the IECs of both UC and CD. Shown are normal, nondiseased mucosae of the terminal ileum (A) and colon (B); inactive (C) and active (D) UC cells; and active, noninvolved CD terminal ileum cells (E) and active, involved CD colon cells (F). (Olympus IX70; original magnification, ×40; standardized exposure time, 1.039 s; full image area, gain 16; gamma adjust, 1.20; noise filter, no background subtraction.)