Table 1.

Body weight, length of estrous cycle, and relative organ weight of the different experimental groups at the end of 14 days of topical vaginal treatment with gel formulation (5, 10 and 15%) from E. uniflora.

Parameter	Naive	Placebo	5%	10%	15%
Body weight (g)	218 ± 6.3	221 ± 7.2	219 ± 6.9	220 ± 7.7	222 ± 7.1
Estrous cycle (days)	4.7 ± 0.3	4.6 ± 0.2	4.6 ± 0.3	4.8 ± 0.3	4.7 ± 0.2
Liver (%)	3.79 ± 0.11	3.52 ± 0.10	3.70 ± 0.05	3.51 ± 0.12	3.32 ± 0.20
Spleen (%)	0.25 ± 0.01	0.24 ± 0.01	0.25 ± 0.01	0.24 ± 0.01	0.24 ± 0.01
Kidneys (%)	0.42 ± 0.01	0.41 ± 0.01	0.40 ± 0.01	0.39 ± 0.01	0.41 ± 0.02
Reproductive organs (%)	0.22 ± 0.02	0.22 ± 0.02	0.19 ± 0.01	0.23 ± 0.01	0.24 ± 0.03

Statistical analyses were performed using one–way ANOVA followed by Bonferroni’s post-hoc test. Values are expressed as mean ± SEM (standard error of the mean). n = seven rats per group.