Table 5.

Biochemical parameters of the different experimental groups at the end of 14 days of topical vaginal treatment with gel formulation (5, 10 and 15%) from E. uniflora.

Parameter	Naive	Placebo	5%	10%	15%
Total protein (g/dL)	6.14 ± 0.51	6.33 ± 1.11	6.32 ± 0.55	6.34 ± 0.62	6.31 ± 0.55
Albumin (g/dL)	4.11 ± 0.32	3.99 ± 0.66	3.87 ± 0.78	4.01 ± 0.40	4.04 ± 0.69
Globulin (g/dL)	2.33 ± 0.23	2.23 ± 0.33	2.40 ± 0.29	2.42 ± 0.39	2.28 ± 0.39
AST (U/L)	126.73 ± 41.23	121.66 ± 55.42	130.22 ± 41.23	120.12 ± 41.74	131.33 ± 41.23
ALT (U/L)	55.57 ± 11.20	61.12 ± 8.30	51.5 ± 9.98	49.15 ± 10.53	59.17 ± 11.30
GGT (U/L)	1.52 ± 0.54	1.47 ± 0.58	1.55 ± 0.69	1.67 ± 0.66	1.62 ± 0.64
AP (U/L)	104.15 ± 55.22	112.34 ± 47.49	114.6 ± 42.27	111.13 ± 54.45	115.15 ± 75.12
TB (mg/dL)	0.047 ± 0.017	0.046 ± 0.017	0.049 ± 0.016	0.050 ± 0.020	0.049 ± 0.019
TG (mg/dL)	77.12 ± 7.01	71.22 ± 8.12	69.22 ± 9.03	73.11 ± 8.76	69.72 ± 9.11
TC (mg/dL)	60.17 ± 11.02	61.57 ± 10.04	59.11 ± 9.02	60.25 ± 8.12	68.17 ± 10.02
HDL-C (mg/dL)	28.22 ± 6.14	30.29 ± 7.11	32.37 ± 9.11	30.71 ± 9.21	29.11 ± 8.84
VLDL-C (mg/dL)	13.12 ± 3.12	12.11 ± 3.01	11.44 ± 4.01	11.04 ± 3.42	10.82 ± 3.99
LDL-C (mg/dL)	21.11 ± 3.23	25.33 ± 4.11	26.13 ± 5.03	24.21 ± 3.99	22.22 ± 2.83
Creatinine (mg/dL)	0.33 ± 0.08	0.35 ± 0.09	0.39 ± 0.06	0.39 ± 0.07	0.34 ± 0.08
Urea (mg/dL)	50.01 ± 8.31	48.12 ± 6.99	50.99 ± 7.78	53.07 ± 9.11	52.06 ± 10.40
Progesterone (pg/mL)	28.06 ± 7.34	30.11 ± 6.16	26.99 ± 8.79	33.31 ± 9.32	29.11 ± 7.65
Estradiol (pg/mL)	47.22 ± 11.23	54.55 ± 12.21	55.33 ± 10.09	50.12 ± 10.21	45.22 ± 11.33
Free T3 (ng/mL)	0.52 ± 0.11	0.55 ± 0.10	0.53 ± 0.09	0.48 ± 0.09	0.51 ± 0.11
TSH (ng/mL)	4.71 ± 0.70	5.02 ± 0.72	4.99 ± 0.55	5.11 ± 0.99	4.95 ± 0.79

Statistical analyses were performed using one–way ANOVA followed by Bonferroni’s post-hoc test. Values are expressed as mean ± SEM (standard error of the mean). n = seven rats per group.