Figure 2.
Treatment with nilotinib results in differential miRNA expression. (A) Volcano plot showing differentially regulated miRNAs following 3 months of treatment with nilotinib; miRNAs with a −log10 p-value > 2 are displayed in red (significance: p < 0,05). (B) Processing of sequenced miRNAs; miRNAs were analyzed to look for significant alterations in expression using Ingenuity Pathway Analysis (IPA), which revealed 102 distinct miRNAs that targeted 15,161 genes. (C) Gene ontology analysis revealed that autophagy, immunity, and neurodegenerative disease pathogenesis were the pathways most targeted by both up and downregulated miRNAs following nilotinib treatment, identifying a series of genes associated with these pathways that are targeted by selected miRNAs.