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Summary of old antibiotics with clinical potential against gram (-) isolates.
| Old Antibiotics | E. coli | K. pneumoniae | P. aeruginosa | A. baumannii |
|---|---|---|---|---|
| Colistin | - | - | - | - |
| Polymyxin B | ✓ | ✓ | - | ✓ |
| Temocillin | ✓ | ✓ | - | - |
| Fosfomycin | ✓ | ✓ | - | - |
| Mecillinam | ✓ | - | - | - |
| Minocycline | - | - | - | - |
| Nitrofurantoin | - | - | - | - |
| Chloramphenicol | - | - | - | - |
✓ attain preclinical PKPD targets, - do not attain preclinical PKPD targets.
