Table 3.
Physicochemical characteristics of RhB- or 2-PAM-loaded liposomes and chitosomes, modified with various polymers (0.05%) and storage time: hydrodynamic diameter (Dh, nm); polydispersity index (PdI), and zeta potential (ζ, mV).
| System | CCs, % | Dh, nm | PdI | ζ, mV | Dh, nm | PdI | ζ, mV |
|---|---|---|---|---|---|---|---|
| RhB | |||||||
| 1 day | 1 month | ||||||
| PC (10 mM) | - | 105 ± 2 | 0.10 ± 0.02 | −5 ± 1 | Not stable | ||
| F1 | 0.05 | 131 ± 1 | 0.10 ± 0.03 | 22 ± 1 | 133 ± 1 | 0.12 ± 0.01 | 29 ± 1 |
| F2 | 0.05 | 119 ± 1 | 0.19 ± 0.01 | 32 ± 1 | 121 ± 1 | 0.21 ± 0.01 | 25 ± 1 |
| F3 | 0.05 | 100 ± 1 | 0.12 ± 0.01 | 34 ± 1 | 115 ± 1 | 0.13 ± 0.09 | 30 ± 1 |
| 2-PAM | |||||||
| PC (10 mM) | - | 118 ± 1 | 0.06 ± 0.01 | −7 ± 1 | Not stable | ||
| F1 | 0.05 | 134 ± 1 | 0.06 ± 0.01 | 9 ± 1 | 134 ± 1 | 0.13 ± 0.01 | 16 ± 1 |
| F2 | 0.05 | 113 ± 1 | 0.07 ± 0.01 | 6 ± 1 | 116 ± 1 | 0.07 ± 0.02 | 11 ± 1 |
| F3 | 0.05 | 116 ± 1 | 0.07 ± 0.01 | 6 ± 1 | 115 ± 1 | 0.08 ± 0.01 | 7 ± 1 |