Table 3.

Multivariable Cox regression to identify significant risk factors for all-cause mortality adjusting for age, sex and renal disease.

Parameter	Hazard Ratio (95% Confidence Interval)	p-Value
Medications
Biguanide	0.75 (0.74−0.77)	<0.001
Sulphonylurea	1.18 (1.16−1.20)	<0.001
Insulin	1.98 (1.95−2.02)	<0.001
Thiazolidinedione	1.02 (0.96−1.08)	0.53
Meglitinide	0.92 (0.50−1.72)	0.80
Dipeptidyl peptidase-4 inhibitors	0.63 (0.49−0.82)	<0.001
Glucagon-like receptor peptide-1 agonists	0.67 (0.17−2.67)	0.57
Angiotensin converting enzyme inhibitors/angiotensin receptor blockers	1.25 (1.23−1.26)	<0.001
Beta-blockers	1.17 (1.15−1.19)	<0.001
Calcium channel blockers	1.26 (1.24−1.27)	<0.001
Lipid-lowering agents	1.22 (1.20−1.24)	<0.001
Comorbidities
Coronary heart disease (CHD)	1.49 (1.46−1.51)	<0.001
Atrial fibrillation (AF)	2.03 (1.98−2.09)	<0.001
Heart failure (HF)	2.42 (2.36−2.47)	<0.001
CHD-HF	2.38 (2.29−2.47)	<0.001
CHD-AF	2.18 (2.07−2.30)	<0.001
HF-CHD	2.31 (2.20−2.43)	<0.001
HF-AF	2.55 (2.39−2.73)	<0.001
AF-CHD	2.03 (1.87−2.19)	<0.001
AF-HF	2.44 (2.32−2.57)	<0.001
CHD-HF-AF	2.65 (2.27−3.11)	<0.001
CHD-AF-HF	2.80 (2.55−3.08)	<0.001
HF-CHD-AF	2.77 (2.39−3.22)	<0.001
AF-CHD-HF	2.10 (1.74−2.53)	<0.001
HF-AF-CHD	2.03 (1.70−2.42)	<0.001
AF-HF-CHD	2.81 (2.39−3.31)	<0.001
Peripheral vascular disease	1.80 (1.59−2.02)	<0.001
Neurological diabetic complications	1.42 (1.32−1.53)	<0.001
Ophthalmological diabetic complications	1.93 (1.83−2.02)	<0.001
Ischemic stroke and transient ischemic attack	1.72 (1.67−1.76)	<0.001
Intracranial hemorrhage	1.35 (1.10−1.66)	<0.001
Osteoporosis	2.41 (2.32−2.51)	<0.001
Dementia	1.67 (1.64−1.69)	<0.001
Hypertension	2.06 (1.91−2.23)	<0.001
Chronic obstructive pulmonary disease	1.73 (1.69−1.77)	<0.001
Cancer	1.35 (1.10−1.66)	<0.001