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(A) Control group with normal histological appearance. (B) DEN group with intense degeneration (arrows) and necrosis (arrowheads) of neurons. (C) DEN + A1 with moderate degeneration (arrows) and necrosis (arrowheads) in neurons. (D) DEN+ A2 with mild degeneration (arrows) and necrosis (arrowheads) in neurons. DEN: diethylnitrosamine, A1: 0.8 g/kg artichoke, A2: 1.6 g/kg artichoke; H&E, Bar: 20 µm.
