Table 3.
Minimum inhibitory concentration range (μg/mL) of various antimicrobial agents for Mycoplasma ovipneumoniae isolates from sheep and goats.
| Antimicrobial Agent | Animal (Number of Isolates Tested) | Geographical Origin and Year of Isolation | MIC Range (μg/mL) | Ref. | |
|---|---|---|---|---|---|
| Fluoroquinolones | Enrofloxacin | Sheep (28) | France, 2007–2018 | ≤0.0625–0.125 | [19] |
| Sheep (12) | BH, 2009 | <0.03–0.125 | [25] | ||
| Sheep (4) | UK, 2010 | <0.12 | [8] | ||
| Sheep (27) | UK, 2003–2004 | 0.03–4.00 | [2] | ||
| Goat (28) | France, 2012–2017 | ≤0.0625–0.25 | [19] | ||
| Goat (12) | BH, 2010, 2011, 2015; Republic of Kosovo, 2008 | <0.03–0.5 | [25] | ||
| Ciprofloxacin | Sheep (12) | BH, 2009 | <0.03 | ||
| Sheep (27) | UK, 2003–2004 | <0.12–2 | [2] | ||
| Goat (12) | BH, 2010, 2011, 2015; Republic of Kosovo, 2008 | <0.03–0.5 | [25] | ||
| Norfloxacin | Sheep (12) | BH, 2009 | <0.03–0.25 | ||
| Sheep (27) | UK, 2003–2004 | <0.12–32 | [2] | ||
| Goat (12) | BH, 2010, 2011, 2015; Republic of Kosovo, 2008 | 0.0625–8 | [25] | ||
| Danofloxacin | Sheep (4) | UK, 2010 | <0.12 | [8] | |
| Sheep (27) | UK, 2003–2004 | <0.06–8 | [2] | ||
| Marbofloxacin | Sheep (4) | UK, 2010 | <0.12 | [8] | |
| Aminoglycosides | Gentamicin | Sheep (12) | BH, 2009 | 0.25–8 | [25] |
| Goat (12) | BH, 2010, 2011, 2015; Republic of Kosovo, 2008 | 0.125–2 | |||
| Spectinomycin | Sheep (28) | France, 2007–2018 | 2–8 | [19] | |
| Sheep (12) | BH, 2009 | 0.5–4 | [25] | ||
| Sheep (4) | UK, 2010 | 1–2 | [8] | ||
| Sheep (27) | UK, 2003–2004 | 0.5–64 | [2] | ||
| Goat (28) | France, 2012–2017 | 2–4 | [19] | ||
| Goat (12) | BH, 2010, 2011, 2015; Republic of Kosovo, 2008 | 0.5–128 | [25] | ||
| Streptomycin | Sheep (40) | New Zealand, 1975 | 6.2–>100 | [24] | |
| Tetracycline | Oxytetracycline | Sheep (28) | France, 2007–2018 | ≤0.0625–4 | [19] |
| Sheep (12) | BH, 2009 | 0.125–0.25 | [25] | ||
| Sheep (4) | UK, 2010 | <0.12 | [8] | ||
| Sheep (27) | UK, 2003–2004 | 0.06–8 | [2] | ||
| Sheep (40) | New Zealand, 1975 | 0.25–1.5 | [24] | ||
| Goat (28) | France, 2012–2017 | ≤0.0625–1 | [19] | ||
| Goat (12) | BH, 2010, 2011, 2015; Republic of Kosovo, 2008 | 0.0625–32 | [25] | ||
| Macrolide | Tylosin | Sheep (12) | BH, 2009 | <0.03–0.25 | |
| Sheep (4) | UK, 2010 | <0.12–0.25 | [8] | ||
| Sheep (27) | UK, 2003–2004 | 0.06–>64 | [2] | ||
| Sheep (40) | New Zealand, 1975 | 0.1–6.2 | [24] | ||
| Goat (12) | BH, 2010, 2011, 2015; Republic of Kosovo, 2008 | <0.03–128 | [25] | ||
| Erythromycin | Sheep (4) | UK, 2010 | 0.25–1 | [8] | |
| Sheep (27) | UK, 2003–2004 | 8–32 | [2] | ||
| Sheep (40) | New Zealand, 1975 | 62–>1000 | [24] | ||
| Tilmicosin | Sheep (28) | France, 2007–2018 | 2–32 | [19] | |
| Sheep (4) | UK, 2010 | 1–2 | [8] | ||
| Sheep (27) | UK, 2003–2004 | 0.25–>64 | [2] | ||
| Goats (28) | France, 2012–2017 | 2–≥16 | [19] | ||
| Tulathromycin | Sheep (4) | UK, 2010 | 0.5 | [8] | |
| Phenicol | Florfenicol | Sheep (28) | France, 2007–2018 | 2–8 | [19] |
| Sheep (12) | BH, 2009 | 0.5–4 | [25] | ||
| Sheep (4) | UK, 2010 | 2–<32 | [8] | ||
| Sheep (27) | UK, 2003–2004 | 0.5–16 | [2] | ||
| Goat (28) | France, 2012–2017 | 2–8 | [19] | ||
| Goat (12) | BH, 2010, 2011, 2015; Republic of Kosovo, 2008 | <0.03–8 | [25] | ||
| Chloramphenicol | Sheep (4) | UK, 2010 | 8 | [8] | |
| Sheep (27) | UK, 2003–2004 | 1–32 | [2] | ||
| Sheep (40) | New Zealand, 1975 | 1.5–100 | [24] | ||
| Pleuromutilin | Tiamulin | Sheep (12) | BH, 2009 | 0.125–0.5 | [25] |
| Goat (12) | BH, 2010, 2011, 2015; Republic of Kosovo, 2008 | <0.03–0.5 | |||
| Lincosamide | Clindamycin | Sheep (27) | UK, 2003–2004 | <0.12–2 | [2] |
| Lincomycin | Sheep (28) | France, 2007–2018 | 1–4 | [19] | |
| Sheep (4) | UK, 2010 | 0.5 | [8] | ||
| Sheep (27) | UK, 2003–2004 | 0.25–8.00 | [2] | ||
| Goat (28) | France, 2012–2017 | 1–≥16 | [19] | ||
| Aminocoumarins | Novobiocin | Sheep (40) | New Zealand, 1975 | 1.5–25 | [24] |