Table 1.

In vitro anticancer effects of nanoformulated EOs and individual secondary metabolites isolated from EOs or herbal extracts.

Formulation	Plant EO or Constituent of EO	Tested Human Cancer Cell Lines	Refs.
NEs	carvacrol	lung adenocarcinoma A549 cells	[104]
	carvacrol	doxorubicin resistant-A549 cells	[106]
	Carum carvi EO	HT-29 colorectal adenocarcinoma cells	[111]
	Cuminum cyminum seed EO	SAS tongue carcinoma cells	[112]
	Anethum graveolens EO	lung adenocarcinoma A549 cells	[114]
	Ferula assa-foetida EO	MCF-7 breast cancer cells, mammary cancer tissue	[116]
	Ferula gummosa EO	HT-29 colorectal adenocarcinoma cells	[117]
	Heracleum persicum EO	MDA-MB-231 breast cancer cells	[118]
	Apium graveolens EO	SAS tongue carcinoma cells	[119]
	Origanum vulgare EO	PC3 prostate cancer cells	[120]
	Origanum glandulosum Desf. EO	HepG2 liver cancer cells	[121]
	Mentha piperita EO	MCF-7, MDA-MB-231, MDA-MB-468 breast cancer cells	[122]
	Mentha arvensis EO	HTh-7 thyroid cancer cells	[123]
	Mentha spicata EO	KON oral squamous carcinoma cells	[124]
	Lavandin EO	MCF-7 breast cancer cells, CCRF-CEM lymphoblastic leukemia cells, Caco-2 colorectal adenocarcinoma cells	[125]
	Zataria EO	MCF-7, MDA-MB-231 breast cancer cells	[126]
	Zataria multiflora EO	MCF-7, MDA-MB-231 and T47D breast cancer cells	[127]
	Saccocalyx satureioides Coss. et Durieu EO	HepG2 liver cancer cells	[128]
	Teucrium polium L. EO	HCT 116 and HT-29 colorectal adenocarcinoma cells	[129]
	Jasminum humile EO	HepG2 liver cancer cells, MCF-7 breast cancer cells	[131]
	Jasminum grandiflorum EO	HepG2 liver cancer cells, MCF-7 breast cancer cells	[131]
	Santolina chamaecyparissus EO	MCF-7 breast cancer cells, HepG2 liver cancer cells, Caco-2 colorectal adenocarcinoma cells	[132]
	Pulicaria crispa EO	MCF-7 breast cancer cells, HepG2 liver cancer cells	[133]
	Linum usitatissimum seed EO	A2780 ovarian cancer cells	[134]
	Artemisia vulgaris EO	MCF-7 breast cancer cells	[135]
	Artemisia cina EO	lung adenocarcinoma A549 cells	[136]
	Myrtus communis EO	A-375 melanoma cells	[137]
	Syzygium aromaticum EO	HT-29 colorectal adenocarcinoma cells	[138]
	Syzygium aromaticum buds EO	HTh-7 thyroid cancer cells	[139]
	frankincense resin	lung adenocarcinoma A549 cells	[140]
	Zingiber ottensi EO	MCF-7 breast cancer cells	[141]
	Nigella sativa EO	MCF-7 breast cancer cells.	[143]
	Nigella sativa EO	HepG2 and Huh-7 liver cancer cells	[144]
	Pistacia atlantica EO	lung adenocarcinoma A549 cells	[147]
	Pinus morrisonicola needle EO	HT-29 colorectal adenocarcinoma cells	[148]
	Citrus aurantium bloom EO	lung adenocarcinoma A549 cells	[149]
	Drimys angustifolia EO	U-138 MG glioblastoma cells, T24 bladder carcinoma cells	[150]
	Ricinus communis EO	HepG2 liver cancer cells	[151]
Liposomes	Curcuma wenyujin EO	HeLa cervical cancer cells, laryngocarcinoma Hep-2 cells, HL-60 promyelocytic leukemia cells, U251 human glioma cells	[158]
	Curcuma longa EO	Lewis lung cancer cells	[159]
	Citrus bergamia EO	SH-SY5Y neuroblastoma cells	[160]
	Achillea millefolium EOs	MCF-7 breast cancer cells	[161]
	Origanum vulgare L. EO	MCF-7 breast cancer cells	[162]
	Rosmarinus officinalis EO	MCF-7 breast cancer cells	[163]
	Brucea javanica EO	HepG2 liver cancer cells	[166]
SLNPs	cuminaldehyde	lung adenocarcinoma A549 cells, HCT 116 colorectal adenocarcinoma cells	[174]
	linalool	HepG2 liver cancer cells, lung adenocarcinoma A549 cells	[175]
	Foeniculum vulgare EO	MCF-7 breast cancer cells	[176]
	Ferula assa-foetida seed EO	NTERA-2 embryocarcinoma cells	[177]
	Mentha longifolia EO	MDA-MB-468 and MCF-7 breast cancer cells	[178]
	Mentha pulegium EO	MDA-MB-468 and MCF-7 breast cancer cells	[178]
	Zataria multiflora EO	MDA-MB-468 breast cancer cells, A-375 melanoma cells	[179]
	Satureja khuzistanica EO	MCF-7 breast cancer cells	[180]
	Pistacia atlantica EO	MDA-MB-231 breast cancer cells	[181]
NLCs	eucalyptol	MDA MB-231 breast cancer cells	[188]
	lavender EOs	SK-MEL-25 melanoma cells	[189]
	Pistacia atlantica Desf EO	SK-BR-3 breast cancer cells	[190]