ADME	Absorptions, distribution, metabolism, and elimination
AEP	Aggregate exposure pathway
AOP	Adverse outcome pathway
BMD	Benchmark dose
CFD	Computational fluid dynamics
CFPD	Computational fluid particle dynamics
CORESTA	Cooperation Centre for Scientific Research Relative to Tobacco
DA	Defined approach
ENDS	Electronic nicotine delivery system
GRAS	Generally recognized as safe
HEC	Human equivalent concentration
IATA	Integrated approaches to testing and assessment
IVIVE	In vitro to in vivo extrapolation
KE	Key event
LADD	Lifetime average daily dose
LD/LC50	Lethal dose/concentration at 50%
NAMs	New approach methodologies
NGO	Non-governmental organization
NOAEL	No observable adverse effect level
PBPK	Physiologically based pharmacokinetic
PSLT	Poorly soluble low toxicity
QRA	Quantitative risk assessment
SME	Subject matter expert
SSPT	Smoke-Science and Product Technology
TSE	Target site exposure
TSCA	Toxic Substances Control Act