Table 2.
Citrullinated peptides as targets of ACPAs.
| Protein | Sequence | PTM Peptide | References |
|---|---|---|---|
| Filaggrin | (306–324) (304–324) |
SHQESTCitGRSRGRSGRSGS (cyclic) HQCESTCitGRSRGRCGRSGS (cyclic) HQCHQESTCitGRSRGRCGRSGS (cyclic) HSGIGHGQASSAVRDSGHCitGYS HSTSQEGQDTIHGHCitGS |
[81,93] [94,95,96,97,98] [81,91,99] [55] [55] |
| Profilaggrin | (293–310) | TIHAHPGSCitCitGGRHGYHH TIHAHPGSCitRGGCitHGYHH |
[100] |
| Fibrinogen (α-chain) | (27–43) (31–50) (36–50) (41–60) (84–96) (211–230) (556–575) (563–583) (580–600) (616–636) (617–631) (621–635) |
FLAEGGGVCitGPRVVERH GGGVCitGPRVVERHQSACKDS GPCitVVECitHQSASKDS ECitHQSACKDSDWPFCSDEDW (cyclic) TSSTSYNCitGDSTF DLLPSCitDRQHLPLIKMKPVP (cyclic) NTKESSSHHPGIAEFPSCitGK (cyclic) HHPGIAEFPSCitGKSSSYSKQF SKQFTSSTSYNCitGDSTFESKS THSTKCitGHAKSCitPVCitDCDDVL (cyclic) HSTKRGHAKSRPVCitG CitGHAKSCitPVCitGIHTS |
[56,95] [100] [86,91,93,94,98,101] [102] [95] [102] [97,102] [91,93,94,96,98,103] [91,93,94,98,103] [100,102] [83] [86,91,93,94,96,98,101] |
| Fibrinogen (β-chain) | (36–52) (43–62) (60–74) (54–80) (62–81) (62–81) |
NEEGFFSACitGHRPLDKK ARGHCitPLDKKREEAPSLCitPA CitPAPPPISGGGYCitACit EEAPSLCitPAPPPISGGGYCitACitPAKAAA APPPISGGGYCitARPAKAAAT APPPISGGGYRACitPAKAAAT |
[56,91,93,94,96,97,98] [83] [86,91,93,94,96,98,101] [95] [94,96,97,103] [94,96,97,103] |
| Fibronectin | (1029–1042) (2350–2362) |
LTVGLTCitCitGQPRQY YNQYSQCitYHQRTN |
[95] [95] |
| Vimentin | (2–17) (47–72) (59–70) (60–75) (265–278) (420–435) |
STCitSVSSSSYCitCitMFGG STSRSLYASSPGGVYATRSSAVRLCitS GRVYATCitSSAVR VYATRSSAVRLCitSSVP LTAALCitDVCitQQYES SLNLCitETNLDSLPLVD |
[56,93,94,96,97,98] [84] [104,105] [56,93,94,96,97,98] [95] [95] |
| α-enolase | (5–21) | CKIHACitEIFDSCitGNPTVEC (cyclic) | [56,85,91,93,94,95,96,97,98] |
| Collagen type II Collagen type II (citC1III) |
(282–298) (359–369) |
GLPGVKGHCitGYPGLDGA (GPO)5-GACitGLTGCitPGDA(GPO)2-GKKYG |
[95] [91,96,97,98] |
| Biglycan | (247–266) | EDLLCitYSKLYCitLGLGHNQIR (cyclic) | [90,102] |
| Clusterin | (221–240) (334–353) |
PKSCitIVCitSLMPFSPYEPLNF (cyclic) AECitLTCitKYNELLKSYQWKML |
[90,102] [100] |
| β-actin | (191–216) | MKILTECitGYSFTTAECitEIVCitDIKEKL | [95] |
| MNDA | (121–135) | KLTSEACitGCitIPVAQK | [95] |
| Histone 2A Histone 2B |
(1–20) (62–81) |
MSGCitGKTGGKACitAKAKSCitSS (cyclic) IMNSFVNDIFECitIAGEASCitL (cyclic) |
[90,102] [90,102] |
| Histone 4 | (33–47) | AIRRLACitCitGGVLRIS | [62] |
| Tenascin C | (2176–2200) | EHSIQFAEMKLCitPSNFCitNLEGCitCitKR | [106] |
Collagen type II (citC1III): triple-helical type II collagen peptide C1; GPO: glycine-proline-hydroxyproline repeats; MNDA: myeloid nuclear differentiation antigen.