Table 3.
Post-translationally modified peptides as targets of AMPAs: PTM-peptide sequences from different proteins that have shown cross-reactivity with AMPAs in RA patients.
| Protein | PTM | Peptide Sequence | References |
|---|---|---|---|
| Filaggrin | Homocitrulline Acetyl-Lysine |
HQCHQESThCitGRSRGRCGRSGS HQCHQESTKAcGRSRGRCGRSGS |
[99] |
| Vimentin | Homocitrulline Acetyl-Lysine Acetyl-ornithine |
GRVYAThCitSSAVR GRVYATKAcSSAVR GRVYATOrAcSSAVR |
[93,104,105,108,109] |
| Vimentin | Homocitrulline Acetyl-Lysine |
VYAThCitSSAVhCitLhCitSSVP VYATKAcSSAVKAcLKAcSSVP |
[99] |
| Fibrinogen α | Homocitrulline Acetyl-Lysine |
FLAEGGGVhCitGPRVVERH FLAEGGGVKAcGPRVVERH |
[99] |
| Fibrinogen β | Homocitrulline | ARGHRPLDKhCitREEA | [93,109] |
| Fibrinogen β | Homocitrulline | AKAAATQhCitKVER (cyclic) | [93,109] |
| Fibrinogen β | Homocitrulline Acetyl-Lysine |
NEEGFFSAhCitGHRPLDKK NEEGFFSAKAcGHRPLDKK |
[99] |
| Fibrinogen γ | Carbamylation | QKIVNLKEKVAQLEAQCQEPCKDTVQI * WMNKCHAGHLNGVYYQGGTYSKASTPN * |
[110] |
| Enolase | Homocitrulline Homocitrulline Acetyl-Lysine |
KIHAhCitEIFDShCitGNPTVE (cyclic) KIHAhCitEIFDShCitGNPTV (linear) KIHAKAcEIFDSKAcGNPTV (linear) |
[93,111] [99] |
| Histone 2B | Acetyl-Lysine | SAPAPKKAcGSKKAVTKAQ (cyclic) | [93,112] |
| Histone 4 | Acetyl-Lysine Acetyl-Lysine Acetyl-Lysine |
SGRGKAcGGKAcGLGKAcGGAKAcRH SGRGKAcGGKGLGKGGAKRH SGRGKGGKGLGKGGAKAcRH |
[93,112] |
hCit: homocitrulline; KAc: acetyl-lysine; OrAc: acetyl-ornithine; * the position of post-translational modifications are not indicated in Ref. [110].