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. 2022 Dec 15;23(24):15970. doi: 10.3390/ijms232415970

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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scRNA-seq analysis highlighted the role of iCAFs in BCa: (A) CAFs and corresponding two subpopulations (iCAFs and mCAFs) were identified by previously reported markers, including COL1A1, PDGFRA, and RGS5, respectively. Vlnplots demonstrated the expression levels of each marker in the ten clusters. t-SNE plots demonstrated the expression levels of each marker in Cluster 4 and 7 that was named iCAFs and mCAFs, respectively. (B) The heatmap illustrated the expression differences in the top 10 cell-type specific markers between iCAFs and mCAFs. Colors ranging from blue to red represented the expression from low to high. (C) GO (bar-plot, left) and KEGG (dot-plot, right) by ORA demonstrated the enriched terms by markers of iCAFs (up) and mCAFs (bottom). (D) GSEA showed upregulated cancer hallmarks in iCAFs (up) and mCAFs (bottom), respectively.