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. 2022 Dec 15;23(24):15970. doi: 10.3390/ijms232415970

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

iCAF-related subtypes predicted prognosis and immunotherapeutic response in IMvigor210: (A) Two clusters were identified through iCAF-related signature-based consensus clustering. Patients in Cluster 1 were related to a poorer prognosis compared to those in Cluster 2. (B) A stacked bar-plot showed that Cluster 1 had a higher proportion of responders compared to Cluster 2. p value was determined by Chi-squared test. R: responder, NR: non-responder. (C) Cluster 1 had significantly higher iCAF-related scores compared to Cluster 2. iCAF-related score of each IMvigor210 sample was determined by ssGSEA. (D) Cluster 1 was related to high TMB.