Table 2.

PC and interaction with immune system cells other than macrophages.

Cell Type	Type of NP Studied	Cell’s Receptors Involved	Effect
Dendritic cells	C-opsonized FeO-DEX NPs [112]	CR3	Increased NPs’ binding/uptake Lower MCHII and CD86 expression Lower responsiveness to stimuli
	OVA-loaded LPS-modified (PLGA)-NPs [113]	TLRs and NLRs	Increased uptake Stimulation of CD8+ T cell responses
Neutrophils	DEX-coated NPs BNF-starch NPs [112]	CR3 or SR-A	Increased clearance
	IgG-coated PEG-SWCNTs [114,115,116]	IgG mediated Interaction	Neutrophil activation ROS and MPO release
B cells	C-opsonized FeO-DEX NPs [112]	CR-1/2	Decrease in CD86 Lower responsiveness to stimuli
T cells	Unfolded proteins-coated CNTs [106]	Not addressed	Increase in effector T helper cells Reduction of naïve T cells

C: complement; FeO: iron oxide; DEX: dextran; NPs: nanoparticles; CR: complement receptor; MCHII: major histocompatibility complex II; OVA: ovalbumin; LPS: lipopolysaccharide; PLGA: poly(lactic-co-glycolic acid); TLRs: Toll-like receptors; NLRs: nucleotide oligomerization domain (NOD)-like receptors; BNF: bionized nanoferrite; SR: scavenger receptor; PEG: polyethylene glycol; SWCNTs: single walled carbon nanotubules; IgG: immunoglobulin G; ROS: reactive oxygen species; MPO: myeloperoxidase.