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Animal experiment procedure of UVB irradiation on HR-1 mice. After adaptation, the dorsal skin of the HR-1 mice was irradiated to UVB (290 to 320 nm) at one minimal erythema dose (MED, 60 mJ/cm2) for two weeks, two MED (120 mJ/cm2) for one week, three MED (180 mJ/cm2) for one week, and four MED (240 mJ/cm2) for the last eight weeks.
