Figure 9.
Molecular docking of integracide J (6) in stable human 5-LOX (PDB: 6N2W). (A) Molecular surface representation with solid style and electrostatic potential color scheme of red, white, and blue (min −0.3, max +0.3); (B) Zoomed look of integracide J (6) in the active site of 5-LOX in molecular surface; (C) 2D representation of binding interactions of integracide J (6) with amino acid residues in the active site within 4Å distance; (D) 3D representation of integracide J (6) in green color within the active site of 5-LOX. The H–bond interactions are displayed in yellow dotted lines.