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Two conceivable mechanisms for the enzymatic mode of action of DXR involving a divalent metal cation M2+ (grey sphere) and NADPH [87]. Used with permission of EUREKA SCIENCE, from Targeting the MethylErythritol Phosphate(MEP) Pathway for Novel Antimalarial, Antibacterial and Herbicidal Drug Discovery: Inhibition of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase (DXR) Enzyme, Nidhi Singh, Volume 13, Issue 11, 2007; permission conveyed through Copyright Clearance Center, Inc.
