Table 3.
Nonsynonymous nucleotide substitutions in the glycoprotein gene and putative amino acid substitutions during ten serial passages of field RABV isolates in the neuronal cell line.
Isolate | Substitution | |||||
---|---|---|---|---|---|---|
Host | nt | Position * | aa | Position * | Passage no. | |
1069/18 | Great fruit-eating bat | GGG–GAG | 613 | G–E | 186 | 3 |
IP3629/11 | Dog | CGG–CAG | 1055 | R–Q | 333 | 6 |
203/21 | Mexican free-tailed bat | TCC–CCC | 550 | S–P | 165 | 6 |
1833/21 | Great fruit-eating bat | GGG–AGG | 613 | G–R | 186 | 5 |
TCT–TTT | 620 | S–F | 188 | 8 | ||
2193/21 | Great fruit-eating bat | GGG–AGG | 613 | G–R | 186 | 5 |
TCT–CCT | 619 | S–P | 188 | 6 | ||
2253/21 | White-eared opossum | GGG–AGG | 613 | G–R | 186 | 5 |
TCT–CCT | 619 | S–P | 188 | 6 |
* Position numbered according to RABV isolate Pasteur Virus (PV) sequence (GenBank Accession no. M13215); nt—nucleotide; aa—amino acid.