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. 2022 Dec 2;8(6):2864–2873. doi: 10.3390/tomography8060240

Table 4.

Sensitivity, specificity, and area under the curve values identified by cut-off points of different posterior corneal parameter sets to differentiate eyes with suspect keratoconus from normal corneas and keratoconus from normal ones.

Indices Cut-Off Value ROC AUC Sensitivity (%) Specificity (%)
Normal vs. SKC Normal vs. KC Normal vs. SKC Normal vs. KC Normal vs. SKC Normal vs. KC Normal vs. SKC Normal vs. KC
Total HOAs >0.33 >0.37 0.629 0.963 33.33 91.43 89.81 93.52
Trefoil Z (3, ±3) >0.23 >0.25 0.588 0.93 30.95 84.29 88.89 91.67
Coma Z (3, ±1) >0.03 >0.18 0.667 0.929 88.1 81.43 43.52 87.96
Spherical Z (4, 0) ≤0.05 ≤−0.03 0.753 0.846 100 67.14 36.11 94.44

ROC AUC = receiver operating characteristic area under the curve; vs = versus; SKC = suspect keratoconus; KC = Keratoconus; HOAs = higher-order aberrations; Z = Zernike.