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D/P study of NFT ASDs: (a) dissolved NFT concentration in a donor chamber after 120 min as a function of the applied NFT dose. TM was used as a medium. (b) Transmembrane flux as a function of NFT concentration in the donor phase. TM was used as a medium. (c) Same as (a) except that SIF was used as a medium. (d) Same as (b) except that SIF was used as a medium. Symbols: crystalline NFT (◆), HPMCAS ASD (▲), and Eudragit ASD (●).
